Ethics & Engagement across the Wellcome Trust Major Overseas Programmes
The Global Health Bioethics Network is a ten-year programme (2012-2022) to carry out ethics research and build ethics capacity across the Wellcome Trust’s Major Overseas Programmes (MOPs) in Kenya, Malawi, South Africa, Thailand-Laos, and Viet Nam. The Network is funded by a Wellcome Trust Strategic Award to the Ethox Centre and its partners at the MOPs.
This page will regularly feature current projects at each of the MOPs as well as at the Ethox Centre. If you would like your project to be featured on this page, please email firstname.lastname@example.org
Projects by our 2018 Global Health Bioethics Network Fellows and Post-Docs
The aim of this study is to explore views of research stakeholders about appropriate compensation and benefits for study participation in Malawi and to identify strategies that promote fair compensation and benefit sharing with research stakeholders. The study will follow a qualitative design and data will be collected using semi-structured interviews and focus group discussions.
At OUCRU, Dr. Van Nuil is based in the Clinical Trials Unit conducting ethnographic and social science studies within the context of ongoing and upcoming clinical trials and also works closely with the Public Engagement Unit.
We are interested in the ethical aspect and practicalities of implementing Helsinki guidelines when a trial ends and will use the recently concluded HIV Treatment as Prevention trial as a case study. The trial examined the hypothesis that home-based HIV testing of all individuals in the community followed by immediate antiretroviral therapy (ART) initiation regardless of CD4 count would result in reduced HIV incidence in that community.
This pilot study will assess the experiences and challenges of IRB members in Addis Ababa. We will address their experiences and challenges with respect to trainings obtained and the benefit of training in the review process of study proposal. As well, this study will explore the experiences of members in different types of research proposal.
Projects by our 2017 Global Health Bioethics Network Fellows
We propose a project to understand, in detail, attitudes and perceptions surrounding
vaccination uptake in a community at high risk of low vaccination uptake by both quantitative surveys and qualitative interviews and group discussions.
Chimwemwe's GHBN bursary supports her in her studies for an MSc in Visual, Material and Museum Anthropology with the University of Oxford. She will attend lectures and seminars on current practice and themes in visual, material and museum anthropology as well as a research methods class.
Nou Sanann and Tom Peto: Why are forests foci of malaria transmission in western Cambodia, and what can be done to protect forest workers and prevent forest-acquired malaria undermining malaria elimination in neighbouring villages?
This study aims to understand what goes on in forests in western Cambodia in order to assist the design of acceptable and effective interventions targeted at forest visitors.
This study will assess the acceptability and feasibility of TME and analyze the contribution of community engagement (CE) and other factors to the success of TME to date.
The project looks at sharing of unanonymised data. The primary research objective of this project is to understand what research stakeholders’ perspectives are about research studies sharing and accessing participants’ data that contains identification details.
This bursary project is nested within a larger PHD study exploring ethical issues for HDSS in SSA using a case study methodology. The project aims to describe the similarities and differences between HDSS sites in terms of their history, functioning and context.
Mitsunge Gondwe is a new GHBN Fellow this year, who has taken over this project, originally begun in 2013 by Neema Toto. The informed consent process remains a contentious issue in health research in resource limited settings. No research work has been done in Malawi to assess understanding of participants on informed consent process in different study contexts. This prospective project explores the challenges arising in obtaining informed consent in Paediatric observational and interventional research in general and acute/emergency hospital setting at Queen Elizabeth Central Hospital in Blantyre, Malawi.
Projects by our 2016 Global Health Bioethics Network Fellows
The aim of this study is to investigate health practitioners concerns around the impact of the consent process for (a) surgical procedures, (b) recruiting patients who are awaiting surgical procedures into clinical research studies and (c) factors surrounding the recruitment process that may influence a patient’s decision to participate in either option a or b above from a health care practitioners perspective.
This project aims to strengthen the processes of translating research terminologies used in ICFs for medical research in Kilifi Kenya. This may lead to high quality translation of ICFs, improved consent
administration, and ultimately contribute to ethical conduct of health research at KEMRI Wellcome Trust Research Programme (KWTRP).
Kate Gooding is based in MLW’s Behaviour and Health Group. Part of her role involves close collaboration with the Science Communication team. Together with the team manager and M&E officer, she is working to strengthen monitoring and evaluation of MLW's community and public engagement activities, to support research on emerging engagement issues, and to ensure that plans for engagement are informed by clear goals and evidence.
The aim of the study is to explore community attitudes towards research and its ethics in Cambodia by interpreting what community members know about research and what research means for them.
This research project will focus on the ethical issues in relation to recruitment of teenagers and young people in clinical research in Myanmar. In Myanmar, there is a lack of research in young people and there is a need to develop guidance suited to this particular context.
Projects by our 2015 Global Health Bioethics Network Fellows
The primary research Ms Nguyen will focus on over the next year includes ethical aspects of collaborative research, such as informed consent, benefits and compensation, and the translation and dissemination of research results.
The main aim of the study is to explore people’s perspective on involving Men who have Sex with other Men (MSM) in HIV prevention research and learn from the stakeholders how Facilitated Film Viewings (FFV) as an approach can be integrated in the existing community engagement strategies.
The main aim of the study is to identify ethical challenges faced by FW as they conduct medical research, and to ultimately improve ethical research practice among FW at the institution. We will observe FW interactions with research participants and community members to have an in-depth understanding of the challenges faced. In-depth interviews with key stakeholders will also be carried out. Findings from this study will improve the conduct of ethical research among FW in Malawi.
Projects by our 2014 Global Health Bioethics Network Fellows
The main aim of the study is to explore the bioethics of integrating biometrics within the health care system and in medical research in Malawi through the perceptions of policy makers and communities. This project asks the question: What are the current perceptions of policy makers and communities in response to the integration of biometrics within the health care system and in medical research in Malawi?
This study seeks to examine ethics, beliefs, perceptions and practices in the healthcare of neonates. Although there has been a reduction in the number of deaths in children less than five years of age in low and middle income countries, this rate of reduction has not included those in the neonatal period (infants <four weeks of age). Understanding community practice and beliefs is a vital step in improving neonatal outcomes.
Dr Lindsey Reynolds, Miliswa Magongo, and Ncengani Mthethwa: ‘Representing and intervening’: The ethical and social dimensions of divergent forms of representation in the context of long-term biomedical research in South Africa
This research project is focused on the dynamics of divergent forms of representation in the context of long-term biomedical research in South Africa. More specifically, the project aims to explore the ways in which a variety of actors involved in the research activities of the Africa Centre for Population and Health Studies are asked to represent the Centre to the ‘community’ in which the Centre’s research is based and/or to represent the ‘community’ to the Centre leadership, scientific staff, funders, and other stakeholders.
This study explores the ethical issues associated with linking pathogen data to HIV infections, in particular, the use of phylogenetic analysis results as evidence to prove HIV transmission. The overall objective of this study is to develop an ethics framework that will guide the use of molecular epidemiological approaches in South Africa and serve as a resource for other countries involved in similar work.
Projects by our 2013 Global Health Bioethics Network Fellows
Informed consent process remains a contentious issue in health research in resource limited settings. No research work has been done in Malawi to assess understanding of participants on informed consent process in different study contexts. This prospective project explores the challenges arising in obtaining informed consent in Paediatric observational and interventional research in general and acute/emergency hospital setting at Queen Elizabeth Central Hospital in Blantyre, Malawi.
The proposed project is part of a wider project that aims to find ways in which fieldworkers (frontline workers) involved in research activities can be effectively supported to handle practical and ethical challenges they encounter in their roles.
Although there has been much discussion in the literature about consent and assent in paediatric research, little has been written about the unique challenges in low-income settings. There are additional considerations in these difficult and complex environments where research is most needed and the disease burden is high. This project will examine this area and suggest recommendations for consent and assent in children in low-income settings.
This project will be a collaborative project among OUCRU-VN and many other hospitals across the country such as the Hospital for Tropical Disease, Children’s hospital No.1, Children’s hospital No.2 and the National Hospital for Tropical Disease to gain a good knowledge on what are the essential details and information for informed consent forms for non-clinical trials.
Projects by our 2012 Global Health Bioethics Network Fellows
(In alphabetical order)
This project, which is the first of the series of studies, is to answer the following question: “What are the key success indicators of the T-CAB?" The success will be measured against expectations of key stakeholders. We will explore the expectations of key stakeholders includíng investigators, clinic staff, local communities by using appropriate qualitative research methods eg FGD,IDI, observation. Based on these findings, a bespoke evaluation tool will be developed and piloted.
This project aims to first explore the perceptions of community members in Kilifi regarding what’s perceived as good practice for planning benefits to participants across the different types of research; and how these views can be incorporated into guidelines for researchers on planning for benefits in studies. Secondly, it aims to explore methods for community consultation focusing on questions about benefits.
The focus of my research is on the Health Economics Challenges facing Viet Nam including work on Health Insurance, Government Provision and Payment Models for Vaccines, and Infectious Diseases. My research will also explore the broader ethical and political issues surrounding the application of health economics. Health Economics is currently of great importance in Viet Nam and I hope that through my PhD I can contribute to the growing debate about the way health provision in Viet Nam can be afforded in a sustainable and equitable way.
This project aims at exploring how messages about HIV self-testing travel through community networks. The research will be conducted in and around urban Blantyre where HIV/TB intervention is currently taking place. Participants will be traced through a series of social networks, taking three main starting points to identify an initial sample frame. We hope that this research study will provide an opportunity to further develop the MLW communication of science programme, linking our strengths in the practice of community engagement with our strengths in social science research.
The Village Malaria Worker (VMW) scheme in Cambodia currently covers about 30% of the villages currently at risk of malaria. In villages not yet covered, people are still dying of malaria and other preventable diseases. In this project we aim to set up a sponsorship scheme to recruit individual international sponsors to fund individual VMWs and extend the national scheme. We will develop novel smartphone technology and a dedicated website to enhance communication and reporting. We will design and carry out a study to explore the ethical issues arising from the role of the new VMWs.
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